And, in some cases, turf wars. Length of CNI therapy was defined as the interval during which the drug was prescribed, regardless of dosage. FSGS encompasses different histologic variants, which differ in their epidemiology, clinical course, and response to therapy 3. I asked if the tension between the partners had been evident or if their split came as a surprise. Identifying Factors Associated with Choice of Therapy. Cox regression models using both methods and both conversion factors were fitted and compared with the hazard ratio HR estimates. A logistic regression was performed to identify factors associated with being prescribed any immunosuppressive therapy versus none. Chi-squared or Fisher exact tests were used to compare categorical variables regarding treatment and remission.
Charles Jennette Ronald J. Cox regression models using both methods and both conversion factors were fitted and compared with the hazard ratio HR estimates. Among those prescribed any immunosuppressive therapy, another logistic regression model was fitted to identify variables associated with having been prescribed CNIs with or without glucocorticoids compared with high-dose glucocorticoids alone. Appel, however, happily points out that she has a special button on her computer just for processing orders for the tour. Nachman Find articles by Patrick H. Any treatment with angiotensin—converting enzyme inhibitor, angiotensin receptor blocker, or selective aldosterone blocker was defined as renin-angiotensin-aldosterone system inhibition. Charles Jennette Find articles by J. This study was performed to determine the patient and disease characteristics associated with choice of therapy and estimate the association between choice of early therapy and renal outcome ESRD in primary idiopathic FSGS. CNI therapy started within 3 months of glucocorticoid initiation was considered early therapy. Instead, they went to Buttercup. More recently, a feud erupted in the specialty world of lobster rolls when the co-owners of the Pearl Oyster Bar in Greenwich Village had a falling-out. All subjects provided written informed consent. Cox survival models were also performed in adults only, and results are presented separately. Falk Find articles by Ronald J. Nelson—Aalen adjusted survival curves were generated using the following pattern of covariates: Variables that were not normally distributed were summarized as medians interquartile ranges [IQRs] and compared with Mann—Whitney U tests. Identifying Factors Associated with Choice of Therapy. All authors had access to the primary data; L. Both the Kaplan—Meier survival method and Cox adjusted survival curves were used to visually evaluate the relationship between treatment with immunosuppressive therapy and primary end point ESRD. Jennifer Appel, at her midtown store. Few data are available about their use early in the treatment of FSGS. Calcineurin inhibitors with or without glucocorticoids were not significantly associated with a lower likelihood of ESRD compared with glucocorticoids alone hazard ratio, 0. Results In total, patients were studied treated with glucocorticoids alone, 90 treated with calcineurin inhibitors with or without glucocorticoids, 12 treated with other agents, and not treated with immunosuppressives. Some patients were treated with a CNI and glucocorticoids simultaneously, with the latter given at any dosage. This article has been cited by other articles in PMC. To identify potentially important confounders in the association between the choice of early immunomodulatory therapy and time to ESRD, factors associated with the initiation of treatment with an immunomodulatory agent at all treated versus untreated were investigated. So she asked them either to place advance orders or stop buying the cupcakes altogether.
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